Primary demyelination in experimental canine distemper virus induced encephalomyelitis in gnotobiotic dogs
Identifieur interne : 001E44 ( Main/Exploration ); précédent : 001E43; suivant : 001E45Primary demyelination in experimental canine distemper virus induced encephalomyelitis in gnotobiotic dogs
Auteurs : R. J. Higgins [Suisse] ; S. G. Krakowka [États-Unis] ; A. E. Metzler [Suisse] ; A. Koestner [États-Unis]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 1982-03-01.
English descriptors
- KwdEn :
- Teeft :
- Acta, Acta neuropathol, Adjacent myelinated axons, Astrocyte, Astrocytic cell processes, Axon, Berl, Blood vessels, Canine, Canine distemper, Canine distemper virus, Canine distemper virus infection, Cell cuffing, Cell processes, Cerebellar cortex, Cerebral cortex, Cerebrospinal fluid, Choroid, Choroid plexus, Clinical signs, Demyelinated, Demyelinated axons, Demyelinating, Demyelinating encephalomyelitis, Demyelinating lesions, Demyelination, Direct injury, Distemper, Distemper encephalomyelitis, Distemper virus, Encephalomyelitis, Ependymal, Ependymal cells, Ependymal epithelium, Epithelial cells, Experimental demyelinating encephalomyelitis, Experimental infection, Fourth ventricle, Glial filaments, Gnotobiotic, Gnotobiotic dogs, Granular debris, Grey matter, Higgins, High incidence, Histologic lesions, Hypertrophic astrocytes, Immune mechanisms, Immunoglobulin, Immunoglobulin deposits, Immunologic studies, Inclusion bodies, Intact axons, Intact myelin, Intact myelinated axons, Koestner, Krakowka, Lesion, Light microscopy, Macrophage, Major role, Medulla oblongata, Mononuclear cells, Myelin, Myelin injury, Myelin lamellae, Myelin sheath, Myelinated, Myelinated axons, Neonatal gnotobiotic dogs, Neurologic signs, Neuropathol, Oligodendroglia, Other sites, Phagocytic cells, Plexus, Potential usefulness, Predilection sites, Primary demyelination, Reactive astrocytes, Remyelination, Rostral medullary velum, Routine techniques, Segmental internodal, Sequential, Spinal cord, Subependymal foci, Temporal cortex, Uniform thickness, Viral, Viral antigen, White matter.
Abstract
Summary: Experimental infection of gnotobiotic Beagle dogs at 21 days of age with neurovirulent R252 strain of canine distemper virus (R252-CDV) resulted in a non-suppurative encephalomyelitis. Segmental internodal primary demyelination was found in almost 90% of the dogs from 27 days post inoculation (DPI). Ultrastructurally demyelination was initiated by the insertion of CDV-infected astrocytic processes at nodes of Ranvier with subsequent cleavage of well-preserved myelin from the axolemma. CDV-infected macrophages were consistently involved in myelin phagocytosis. Some remyelination of denuded axons occurred after 35 DPI. Persistent productive infection of the choroid plexus and ependyma in the fourth ventricle was consistently associated with subependymal foci of demyelination. Primary demyelination occurred without detectable CDV-specific virus-neutralizing (CDV-VN) antibody in either serum or cerebrospinal fluid (CSF). There were no immunoglobulin deposits or inflammatory cells within the lesions. These findings indicate that both direct CDV antibody-dependent and CDV antibody-dependent cell-mediated immune mechanisms of cytolysis or myelin destruction are not involved in the genesis of initial primary demyelination. The sequential morphologic and serologic findings in this model of demyelinating encephalomyelitis indicate that direct virus-induced injury has a major role in both the initiation and early progression of primary demyelination.
Url:
DOI: 10.1007/BF00692691
Affiliations:
- Suisse, États-Unis
- Canton de Berne, Canton de Zurich, Michigan, Ohio
- Berne, East Lansing, Zurich
- Université d'État du Michigan, Université de Berne
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000579
- to stream Istex, to step Curation: 000546
- to stream Istex, to step Checkpoint: 000793
- to stream Main, to step Merge: 001E72
- to stream Main, to step Curation: 001E44
Le document en format XML
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Segmental internodal primary demyelination was found in almost 90% of the dogs from 27 days post inoculation (DPI). Ultrastructurally demyelination was initiated by the insertion of CDV-infected astrocytic processes at nodes of Ranvier with subsequent cleavage of well-preserved myelin from the axolemma. CDV-infected macrophages were consistently involved in myelin phagocytosis. Some remyelination of denuded axons occurred after 35 DPI. Persistent productive infection of the choroid plexus and ependyma in the fourth ventricle was consistently associated with subependymal foci of demyelination. Primary demyelination occurred without detectable CDV-specific virus-neutralizing (CDV-VN) antibody in either serum or cerebrospinal fluid (CSF). There were no immunoglobulin deposits or inflammatory cells within the lesions. These findings indicate that both direct CDV antibody-dependent and CDV antibody-dependent cell-mediated immune mechanisms of cytolysis or myelin destruction are not involved in the genesis of initial primary demyelination. The sequential morphologic and serologic findings in this model of demyelinating encephalomyelitis indicate that direct virus-induced injury has a major role in both the initiation and early progression of primary demyelination.</div></front></TEI><affiliations><list><country><li>Suisse</li><li>États-Unis</li></country><region><li>Canton de Berne</li><li>Canton de Zurich</li><li>Michigan</li><li>Ohio</li></region><settlement><li>Berne</li><li>East Lansing</li><li>Zurich</li></settlement><orgName><li>Université d'État du Michigan</li><li>Université de Berne</li></orgName></list><tree><country name="Suisse"><region name="Canton de Berne"><name sortKey="Higgins, R J" sort="Higgins, R J" uniqKey="Higgins R" first="R. J." last="Higgins">R. J. Higgins</name></region><name sortKey="Metzler, A E" sort="Metzler, A E" uniqKey="Metzler A" first="A. E." last="Metzler">A. E. Metzler</name></country><country name="États-Unis"><region name="Ohio"><name sortKey="Krakowka, S G" sort="Krakowka, S G" uniqKey="Krakowka S" first="S. G." last="Krakowka">S. G. Krakowka</name></region><name sortKey="Koestner, A" sort="Koestner, A" uniqKey="Koestner A" first="A." last="Koestner">A. Koestner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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